A　method　of　biomimetic　interface　design　and　multi-objective　optimisation　is　presented　for　the　aim　of　preventing　the　interfacial　delamination　of　composite　scaffolds　for　the　osteochondral　tissue　engineering　application.　The　engineering　structure　model　(6.7±0.71%　of　surface　porosity　and　40°-50°　or　80°-90°　of　distribution　angle)　is　firstly　established　from　the　surface　characterization　of　subchondral　bone　plate,　following　the　biomimetic　interface　model　and　finite　element　models　of　the　osteochondral　composite　assembled　by　PEGDA　hydrogel　chondral　compound　and　P-TCP　ceramic　bone　compound　fabricated　using　laser　stereolithography　and　ceramic　sintering　techniques.　Combined　with　multi-objective　optimisation　approach,　the　parameters,　that　is,　the　diameter　of　pore,　structural　unit　(triangular,　quadrilateral　or　hexagonal　unit),　pore　spacing　(or　side　length),　surface　porosity,　are　identified　as　playing　an　important　role　in　the　pore　formibility　and　interfacial　delamination　between　the　PEGDA　hydrogel　and　P-TCP　ceramic　compound　of　osteochondral　composite.　The　optimized　interfacial　structure　is　defined　as　having　the　charactizations　of　quatrilateral　unit,　surface　porosity　in　a　range　of　5%-15%,　pore　diameter　of　more　than　400　μm,　which　having　a　better　capability　both　to　achieve　pore　formibility　and　to　prevent　delamination.　The　method　discussed　in　this　paper　provides　a　promise　assessment　way　to　integrate　biomimetic　design　with　rapid　manufacturing　of　composite　scaffold.　©　2014　Journal　of　Mechanical　Engineering.