The　serum　lipid　profile　has　become　a　routine　clinical　test　and　used　as　an　important　predictor　for　Alzheimer＇s　disease　(AD),　although　its　predictive　value　remains　undetermined.To　evaluate　the　role　of　serum　lipid　levels　in　predicting　the　risk　of　AD.Meta-analyses　were　conducted　using　Comprehensive　Meta-analyses　(CMA)　software　to　investigate　the　association　between　four　conventional　serum　lipid　profile　parameters　and　the　risk　of　AD,　focused　on　samples　from　Asian.In　total,　3423　AD　patients　and　6127　healthy　participants　were　involved.　The　results　demonstrated　that　AD　patients　showed　higher　LDL-C　and　TC　levels　(SMD　=　0.27,　95%　CI:　0.04-0.51,　p　=　0.02　for　LDL-C;　SMD　=　0.25,　95%　CI:　0.05-0.46,　p　=　0.02　for　TC)　compared　with　those　of　healthy　controls.　People　with　higher　LDL-C　and/or　TC　levels　had　an　increased　risk　of　AD　(OR　=　1.64,　95%　CI:　1.07-2.51　for　LDL-C　and　OR　=　1.58,　95%　CI:　1.10-2.92　for　TC).This　study　provided　evidence　that　serum　LDL-C　and　TC　levels　were　associated　with　the　risk　of　AD　in　Asian　individuals.　The　routine　lipid　profile　may　be　useful　for　AD　diagnosis,　monitoring　and　treatment.