A　simple　and　sensitive　method　based　on　the　combination　of　solid-phase　microextraction　(SPME)　and　high-performance　liquid　chromatography　with　ultroviolet　detection　was　developed　for　the　simultaneous　determination　of　clenbuterol,　salbutamol　and　ractopamine　in　pig　samples.　Parameters　of　the　SPME　procedure　affecting　extraction　efficiency,　such　as　the　type　of　fiber,　extraction　time,　extraction　temperature,　ion　strength,　pH　of　sample　and　stirring　rate,　were　optimized.　The　developed　method　was　validated　according　to　the　International　Conference　on　Harmonization　guidelines.　The　calibration　curves　were　linear　over　a　range　of　0.5-50　mu　g/L　for　clenbuterol　and　ractopamine,　and　0.2-20　mu　g/L　for　salbutamol.　The　limits　of　detection　were　0.1　mu　g/L　for　clenbuterol,　0.05　mu　g/L　for　salbutamol　and　0.1g/L　for　ractopamine,　respectively.　The　averages　of　intra-　and　inter-day　accuracy　ranged　from　79.8　to　92.4%.　The　intra-day　and　inter-day　precision　were　below　9.6%　for　the　three　analytes.　This　method　exhibited　the　advantages　of　simplicity,　rapidity　and　low　solvent　consumption,　and　was　suitable　for　the　monitoring　of　(2)-agonists　residue　in　pig　samples.　Copyright　(c)　2013　John　Wiley　&　Sons,　Ltd.