Conventional　ligament　grafts　with　single　material　composition　cannot　effectively　integrate　with　the　host　bones　due　to　mismatched　properties　and　eventually　affect　their　long-term　function　in　vivo.　Here　we　presented　a　multi-material　strategy　to　design　and　fabricate　composite　scaffolds　including　ligament,　interface　and　bone　multiphased　regions.　The　interface　region　consists　of　triphasic　layers　with　varying　material　composition　and　porous　structure　to　mimic　native　ligament-to-bone　interface　while　the　bone　region　contains　polycaprolactone　(PCL)　anchor　and　microchanneled　ceramic　scaffolds　to　potentially　provide　combined　mechanical　and　biological　implant-bone　fixation.　Finite　element　analysis　(FEA)　demonstrated　that　the　multiphased　scaffolds　with　interference　value　smaller　than　0.5　mm　could　avoid　the　fracture　of　ceramic　scaffold　during　the　implantation　process,　which　was　validated　by　in-vitro　implanting　the　multiphased　scaffolds　into　porcine　joint　bones.　Pull-out　experiment　showed　that　the　initial　fixation　between　the　multiphased　scaffolds　with　0.47　mm　interference　and　the　host　bones　could　withstand　the　maximum　force　of　360.31　+/-　97.51　N,　which　can　be　improved　by　reinforcing　the　ceramic　scaffolds　with　biopolymers.　It　is　envisioned　that　the　multiphased　scaffold　could　potentially　induce　the　regeneration　of　a　new　bone　as　well　as　interfacial　tissue　with　the　gradual　degradation　of　the　scaffold　and　subsequently　realize　long-term　biological　fixation　of　the　implant　with　the　host　bone.　(C)　2015　Elsevier　B.V.　All　rights　reserved.