Twenty　chalcone　derivatives　were　designed　and　synthesized　with　a　view　to　developing　novel　anticandidal　agents.　All　the　compounds　were　evaluated　for　their　antifungal　activity　against　Candida　albicans　(ATCC　10231　and　ten　clinical　isolates).　Most　of　them　exhibited　moderate　anticandidal　potency　with　MIC　values　ranging　from　2.0　to　32.0　mu　g/mL.　Four　compounds　(T4,　T6,　T19,　T20)　displayed　potent　anticandidal　activity　with　MIC　values　of　2.0　mu　g/mL.　Compound　T6　showed　the　most　potent　activity　against　Candida　albicans　(ATCC　10231　and　four　clinical　isolates).　In　addition,　attempts　have　also　been　made　to　correlate　anticandidal　activity　to　physicochemical　properties.　The　results　indicated　that　incorporation　of　halogen　on　the　benzene　ring　is　beneficial　for　anticandidal　activity.