Isobutanol　dehydration　using　gamma-Al2O3　catalysts　to　produce　isobutene　was　carried　out　by　a　fixed　bed　reactor　at　0.1MPa.　The　effects　of　temperature,　weight　hourly　space　velocity,　and　particle　size　of　catalyst　on　the　conversion　of　isobutanol　and　selectivity　of　isobutene　were　investigated　to　find　the　optimum　reaction　conditions　and　get　the　kinetics　information.　The　experimental　results　indicated　that　higher　temperature　could　improve　the　conversion　of　isobutanol　while　a　peak　of　selectivity　of　isobutene　can　be　monitored　with　the　temperature　increasing.　Meanwhile,　increasing　the　flow　rate　leads　to　a　decrease　in　the　conversion　of　isobutanol,　but　showed　little　effect　on　selectivity　of　isobutene.　The　intrinsic　kinetics　model　of　isobutanol　dehydration　over　gamma-Al2O3　was　developed　according　to　the　experimental　results.　The　adsorption　of　isobutanol　was　considered　as　a　rate-determining　step　from　the　analysis　results　of　reaction　mechanism,　and　kinetics　parameters　were　obtained　by　Levenberg-Marquardt　algorithm.　The　calculated　results　agreed　well　with　the　experimental　data.