Objective:　To　investigate　the　distribution　of　ABCB1　C3435T　and　ABCG2　C421A　gene　polymorphisms　in　Chinese　Han　population　and　their　influences　on　the　susceptibility　and　prognosis　of　breast　carcinoma.　Methods:　A　total　of　200　female　subjects　were　enrolled　in　this　study,　comprising　100　breast　cancer　patients　and　100　healthy　controls.　Carcinoma　and　para-carcinoma　tissues　were　collected　from　the　breast　cancer　patients,　while　peripheral　blood　was　collected　from　healthy　controls.　Single　nucleotide　polymorphisms　(SNPs)　were　detected　by　the　Taqman　method.　Progression-free　survival　(PFS)　and　5-year　survival　rate　of　the　patients　were　calculated.　Results:　ABCB1　C3435T　and　ABCG2　C421A　polymorphisms　were　not　associated　with　disease　susceptibility　and　5-year　survival　rate　in　the　study　population　(p＞0.05).　However,　a　high　mutation　rate　of　both　ABCB1　C3435T　and　ABCG2　C421A　(16%　and　17%,　respectively)　was　observed　in　breast　cancer　tissues.　Patients　with　ABCB1　3435TT　genotype　or　ABCG2　421CC　genotype　had　longer　PFS　(p＜0.05).　Conclusion:　ABCB1　3435TT　and　ABCG2　421CC　were　significantly　associated　with　longer　PFS　in　Chinese　breast　cancer　patients.