Background.　Hepatocellular　carcinogenesis　is　associated　with　the　progression　of　cirrhosis,　and　the　latter　further　aggravates　tumor　development　and　prognosis.　The　aim　of　the　study　was　to　investigate　the　prognostic　values　of　12　cirrhosis-relative　non-invasive　models　in　hepatocellular　carcinoma　(HCC).　Methods.　We　retrospectively　analyzed　363　HCC　patients　who　either　underwent　partial　hepatectomy　(PH)　or　received　transcatheter　arterial　chemoembolization　(TCAE).　Preoperative　data　were　collected　to　calculate　these　indices　using　the　original　formulas.　Diagnostic　accuracy　of　these　models　in　detection　of　cirrhosis　was　evaluated　by　area　under　receiver　operating　characteristic　curve　(AUC)　analysis.　Multivariate　analyses　were　performed　to　assess　the　independent　prognostic　significance　of　the　12　indicators.　Results.　Aspartate　aminotransferase-platelet　ratio　index　(APRI)　and　Goteborg　University　Cirrhosis　Index　(GUCI)　were　found　to　be　signifi　cant　in　discriminating　cirrhotic　patients　from　non-cirrhotic　individuals.　When　the　indices　were　expressed　as　continuous　variables,　multivariate　analyses　indicated　that　APRI　and　GUCI　were　independent　indices　to　predict　overall　survival　in　patients　underwent　PH,　with　a　hazard　ratio　(HR)　value　1.04　(p　=　0.005)　and　1.07　(p　=　0.001),　respectively.　In　the　cohort　of　TACE,　APRI　and　GUCI　were　independently　associated　with　survival　as　well.　Conclusion.　Of　the　12　indices,　APRI　and　GUCI　were　relatively　accurate　predictors　of　cirrhosis　status　as　well　as　outcome　of　HCC.　As　only　a　limited　study　population　was　enrolled　in　the　current　study,　larger　cohorts　are　needed　to　validate　our　results.