The　present　study　is　based　on　water　quality　assessment　for　drinking　and　irrigation　purpose　in　10　districts　of　Khyber　Pakhtunkhwa　and　Gilgit-Baltistan,　Pakistan.　A　total　of　181　water　samples　were　collected　with　random　sampling　criteria　and　undergone　quality　assessment　through　the　American　Public　Health　Association　standard　procedures.　Electrical　conductivity　(EC),　turbidity　and　arsenic　were　found　higher　in　drinking　water　than　upper　permissible　limits　of　World　Health　Organization　(WHO)　and　the　National　Environmental　Quality　Standards-Pakistan　(NEQs-Pak).　Multivariate　quality　indexes　were　applied,　water　quality　index　determined　that　overall　water　quality　was　good　for　drinking　purpose.　However,　health　risk　assessment　was　evaluated,　and　results　showed　that　values　of　hazard　index　(HI)　were　near　the　threshold　limit　(HI　＞=　1)　both　in　adult　and　children.　Irrigation　water　quality　for　surface　water　was　determined　by　using　sodium　absorption　ratio　and　magnesium　absorption　ratio　indexes　showed　that　water　used　for　irrigation　purpose　was　in　good　quality.　Permeability　index　was　found　unsuitable　for　surface　water.　However,　EC,　turbidity,　and　arsenic　were　exceeding　a　limit　for　drinking　purpose.　Reducing　anthropogenic　activities　including　waste　disposal,　regular　monitoring　of　water　supplies　and　apply　preventive　measures　can　improve　the　water　quality　status.