This　paper　proposes　a　novel　hybrid　fuel　cell　power　generation　system　with　high　efficiency.　The　thermo-economic　modeling　of　the　MWe-scale　systems　using　different　fuels　is　conducted　to　evaluate　the　economic　feasibility　under　the　subsidy　policy　of　Eastern　China.　This　work　aims　to　develop　the　technology　roadmap　for　this　kind　of　clean　power　system.　It　is　found　that　the　energy　efficiency　of　the　natural　gas　and　biogas　fed　systems　could　reach　up　to　64%　and　63.5%　respectively,　thus　they　are　efficient　and　cost-optimal　for　the　hybrid　system　while　liquefied　petroleum　gas　and　water　gas　yield　low　efficiency　and　high　electricity　cost.　Moreover,　under　the　subsidy　policy,　the　biogas-fed　hybrid　system　is　more　suitable　for　a　small-scale　power　system,　while　the　natural　gas-fed　system　is　preferable　for　the　large-scale　case.　The　specific　electricity　cost　of　small-scale　biogas　hybrid　fuel　cell　power　plant　is　0.365　CNY/kWh,　lower　than　the　present　feed-in-tariff　price　0.475–0.704　CNY/kWh　of　other　biogas　plants　in　China.　Also,　the　cost　of　0.345–0.347　CNY/kWh　of　large-scale　natural　gas-fed　hybrid　system　is　much　lower　than　the　on-grid　electricity　price　0.7655　CNY/kWh　in　Shanghai.　These　results　reveal　that　the　proposed　hybrid　fuel　cell　power　system　is　efficient　and　economically　feasible.　The　payback　period　and　annual　return　on　investment　are　0.8–1.2　year　and　11–12%,　respectively.　©　2020　Elsevier　Ltd