The　low-cost　and　continuous　hydrogen　production　from　waste　has　recently　received　much　attention.　To　achieve　clean　and　efficient　in-situ　resource　utilization,　this　study　proposes　a　novel　hydrogen　production　system　using　medical　waste　and　biogas　with　zero　carbon　emission,　composed　of　plasma　gasification,　solid　oxide　fuel　cell,　steam　turbine　cycle,　and　autothermal　reforming.　The　hybrid　system　is　designed　as　a　poly-generation　system　capable　of　producing　hydrogen,　heat,　and　electricity　to　self-sustain　the　energy　consumption　required　to　produce　hydrogen　for　the　entire　plan.　And　a　thermodynamic　and　techno-economic　of　the　hydrogen　production　system　is　investigated.　The　results　show　that　the　hydrogen　production　process＇s　energy　efficiency　and　exergy　efficiency　from　medical　waste　and　biogas　reach　63.20%　and　59.15%,　higher　than　the　others.　In　addition,　the　system　can　recover　its　initial　cost　in　3.25　years,　and　the　net　present　value　of　the　new　scheme　is　expected　to　reach　125,197.65　k$　over　a　25-year　lifetime.　©　2022　Elsevier　Ltd