The　design　of　a　bio-safe　superhydrophobic　coating　to　repel　water　adsorption,　food　and　blood　adherence　is　significantly　important　to　attenuate　food　spoilage,　food　waste　and　thrombi.　Herein,　we　synthesize　an　all-natural　superhydrophobic　interfacial　material　that　has　strong　interfacial　stability　on　a　variety　of　substrates,　and　has　good　repellence　towater,　highly-viscous　liquid　foods　and　biofluids　(blood,　urine,　etc.).　The　base　material　is　simply　prepared　in　an　aqueous　solution　of　lysozyme　and　cysteine,　in　which　the　rapid　phase　transition　of　lysozyme　is　triggered　by　a　cysteine-induced　thiol-disulfide　exchange　reaction.　The　resulting　phase-transited　lysozyme　(PTL)　aggregates　into　microparticles　with　a　nanoscale　roughness,　which　are　further　packed　into　a　dense　layer　with　a　micro-/nano-topography.　The　PTL　is　composed　of　an　inner　amyloid-like　structure　and　shows　strong　interfacial　adhesion　with　the　underlying　substrate　due　to　amyloid-inspired　adhesion.　The　PTL　layer　is　finally　converted　to　a　robust　coating　to　effectively　repel　liquid　foods　and　biofluids　by　being　decorated　with　a　natural　hydrophobic　carnauba　wax.　This　coating　noticeably　enhances　the　water　repellence　of　cellulose-based　packaging　materials,　and　the　resulting　superhydrophobic　paper　is　completely　non-wetted　by　water　without　weakening　the　mechanical　stability　and　usability　of　the　modified　paper.　The　coating　further　resists　the　adhesion　of　milk,　yogurt,　honey　and　various　other　beverages　and　edible　liquids,　which　leaves　no　residue　on　the　coated　surface.　This　coating　also　significantly　resists　wetting　by　blood　and　other　human　biofluids　with　a　noticeable　decrease　in　platelet　adhesion　on　the　surface.　This　work　underlines　the　importance　of　an　amyloid-like　protein　assembly　in　the　preparation　of　an　all-natural　green　interfacial　coating　towards　the　robust　repellence　of　water,　edible　liquids　and　blood.　©　2020　Elsevier　B.V.