A　high-salt　(HS)　diet　leads　to　metabolic　disorders　in　Dahl　salt-sensitive　(SS)　rats,　and　promotes　the　development　of　hypertension.　According　to　the　changes　in　the　metabolites　of　SS　rats,　a　set　of　combined　dietary　supplements　containing　amino　acids　and　organic　acids　(AO)　were　designed.　The　purpose　of　the　present　study　was　to　evaluate　the　effect　of　AO　supplementation　on　the　blood　pressure　of　SS　rats　after　the　HS　diet　and　clarify　the　mechanism　of　AO　by　metabolomics　and　biochemical　analyses.　The　results　showed　that　AO　supplementation　avoided　the　elevation　of　blood　pressure　induced　by　the　HS　diet　in　SS　rats,　increased　the　renal　antioxidant　enzyme　activities　(catalase,　superoxide　dismutase,　glutathione　reductase,　and　glutathione　S-transferase),　reduced　the　H2O2　and　MDA　levels,　and　restored　the　normal　antioxidant　status　of　the　serum　and　kidneys.　AO　also　reversed　the　decrease　in　the　nitric　oxide　(NO)　levels　and　NO　synthase　activity　induced　by　the　HS　feed,　which　involved　the　l-arginine/NO　pathway.　Metabolomics　analysis　showed　that　AO　administration　increased　the　levels　of　amino　acids　such　as　cysteine,　glycine,　hypotaurine,　and　lysine　in　the　renal　medulla　and　the　levels　of　leucine,　isoleucine,　and　serine　in　the　renal　cortex.　Of　note,　lysine,　hypotaurine　and　glycine　had　higher　metabolic　centrality　in　the　metabolic　correlation　network　of　the　renal　medulla　after　AO　administration.　In　conclusion,　AO　intervention　could　prevent　HS　diet-induced　hypertension　in　SS　rats　by　restoring　the　metabolic　homeostasis　of　the　kidneys.　Hence,　AO　has　the　potential　to　become　a　functional　food　additive　to　improve　salt-sensitive　hypertension.　©　The　Royal　Society　of　Chemistry.