Limited　cellular　delivery　and　internalization　efficiency　of　Al(III)　phthalocyanine　chloride　tetrasulfonic　acid　(AlPcS4)　induce　poor　penetration　ability　in　cells　and　a　slight　photodynamic　therapy　(PDT)　effect　on　gastric　cancer.　The　combination　treatment　of　AlPcS4/PDT　with　low-dose　chemotherapeutic　agents　may　provide　a　promising　treatment　strategy　to　increase　the　weak　delivery　efficiency　of　AlPcS4,　reducing　the　dose　of　chemical　agents　without　reducing　efficacy,　and　improving　apoptosis-inducing　abilities,　thereby　increasing　the　antitumor　effects　and　decreasing　the　noxious　side　effects　on　gastric　cancer.　We　investigated　and　compared　the　synergistic　antitumor　growth　effect　on　gastric　cancer　cells　by　combining　AlPcS4/PDT　treatment　with　different　low-dose　chemotherapeutic　agents,　namely,　5-fluorouracil　(5-FU),　doxorubicin　(DOX),　cisplatin　(CDDP),　mitomycin　C　(MMC),　and　vincristine　(VCR).　The　inhibitory　effect　was　increased　in　treatments　that　combined　AlPcS4/PDT　with　all　the　aforementioned　low-dose　chemotherapeutic　agents,　to　a　different　extent.　An　evident　synergistic　effect　was　obtained　in　the　combination　treatment　of　AlPcS4/PDT　with　low-dose　5-FU,　DOX,　and　MMC　by　increasing　AlPcS4　intracellular　uptake　ability,　improving　apoptosis-inducing　abilities,　and　prolonging　apoptosis-inducing　time.　The　low-dose　chemotherapeutic　agents　prolonged　the　apoptosis-inducing　period　of　AlPcS4/PDT,　and　AlPcS4/PDT　quickly　improved　apoptosis-inducing　abilities　of　chemotherapy　even　at　low　doses.　Generally,　the　combination　treatment　of　AlPcS4/PDT　with　low-dose　chemotherapeutic　agents　had　significant　antitumor　growth　effects　in　addition　to　a　low　dark-cytotoxicity　effect　on　gastric　cancer,　thereby　representing　an　effective　and　feasible　therapy　method　for　gastric　cancer.